P. C. Wilson

The paper investigates how germline alleles influence B cell responses to infection, showing that while they can lead to similar responses, diverse evolutionary paths limit genetic predictability.

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

This study shows that IgG3 subclass antibodies neutralize antigenically drifted influenza and SARS-CoV-2 variants more effectively than other subclasses.

Librator is a platform for sequence editing and design of influenza virus proteins, enabling efficient mutation and chimeric protein creation for vaccine development.

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

The paper functionally and antigenically characterizes the hemagglutinin and neuraminidase of Wuhan spiny eel influenza virus to assess its status as a bona fide influenza virus.

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

The paper shows that anti-vimentin antibodies in lupus nephritis undergo in situ selection for enhanced binding and specificity to vimentin fibrils, challenging the notion of affinity maturation as a non-specific consequence of polyreactivity.

This study identifies H3N2 HA RBS-targeting antibodies in humans, showing some can be broadly reactive despite sensitivity to substitutions near the RBS.

The paper maps how amino-acid mutations in influenza's hemagglutinin affect neutralization by polyclonal human sera, showing individual variation in escape mutations not observed in ferrets.

This study shows HA-stalk-reactive antibodies inhibit neuraminidase activity via steric hindrance, blocking viral egress and enhancing protection against influenza.