ImmunologybioRxivPreprint
In situ humoral selection in human lupus tubulointerstitial inflammation
A. J. Kinloch, Y. Asano, A. Mohsin…·M. R. Clark
The paper shows that anti-vimentin antibodies in lupus nephritis undergo in situ selection for enhanced binding and specificity to vimentin fibrils, challenging the notion of affinity maturation as a non-specific consequence of polyreactivity.
DOI 10.1101/2020.06.29.178145