M. Renner

Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus

The paper determines the structure of the N-RNA/P triple complex in human metapneumovirus, revealing how the polymerase attaches to the RNA template and providing a basis for therapeutic design.

High-efficiency base editing for Stargardt disease in mice, non-human primates, and human retina tissue

This study develops a base-editing strategy to correct the ABCA4 mutation in mice, non-human primates, and human retinal tissue, achieving high editing rates in vivo.

Cryo-electron tomography of large biological specimens vitrified by plunge freezing

This study demonstrates that plunge freezing can vitrify large biological specimens like mouse cardiomyocytes and Drosophila tissues, enabling efficient cryo-FIB/ET analysis of their molecular architecture.

A high resolution view of an adolescent flavivirus

This study presents high-resolution cryo-EM structures of immature and mature flaviviruses, revealing structural changes during maturation and the role of pH in conformational rearrangements.

Topographical cues control the morphology and dynamics of migrating cortical interneurons

This study shows that micro-scale topography influences the morphology and migration of cortical interneurons in vitro, promoting distinct migratory states.

A simple and powerful analysis of lateral subdiffusion using single particle tracking

This paper introduces a new parameter, the packing coefficient, to analyze lateral subdiffusion in biological membranes and demonstrates its application in detecting changes in diffusive behavior.