ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1
M. S. Dickinson, M. Kutsch, L. Sistemich…·J. Coers
This paper shows GBP2 can trigger pyroptosis by aggregating free LPS and activating caspase-4, independent of GBP1's bacterial binding function.
DOI 10.1073/pnas.2216028120