T cell development is regulated by high fidelity replication of mitochondrial DNA
C. Limper, N. B. Bondah, D. Zhu, A. N. Villanueva, U. K. Chukwukere, W. Huang, A. August
This study shows that high fidelity mitochondrial DNA replication is essential for normal T cell development in the thymus, as reduced fidelity leads to premature thymocyte decline.
bioRxiv · Dec 20, 2022 · PreprintImmunology