Cancer BiologybioRxiv
Small Molecule Activators of B56-PP2A Restore 4E-BP Expression and Function to Suppress Cap-dependent Translation in Cancer Cells
M. A. Lum, K. A. Jonas-Breckenridge, A. R. Black…·J. D. Black
DOI 10.1172/jci176093
Author
C. M. O'Connor
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagApproach:experimental assay· 5Organism:human· 5Research Focus:host-pathogen & immune response· 4Research Focus:gene regulatory network inference· 2Research Focus:cancer & tumor microenvironment· 1Research Focus:chromatin & epigenetic regulation· 1Research Focus:differential expression· 1Assay:proteomics· 1
Activity by Year
2018-2022 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 17 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- MicrobiologyProceedings of the National Academy of SciencesPeer-reviewed
Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency
B. A. Krishna, A. B. Wass, C. M. O'Connor
This study identifies AP-1 transactivation of the MIE enhancer as critical for HCMV reactivation from latency, showing its role in de-repressing viral transcripts and downstream genes.
DOI 10.1073/pnas.2009420117 - MicrobiologyFrontiers in Cellular and Infection MicrobiologyPeer-reviewed
The Requirement For US28 During Cytomegalovirus Latency Is Independent Of US27 And US29 Gene Expression
B. A. Krishna, A. B. Wass, R. Sridharan, C. M. O'Connor
This study shows US28 is required for HCMV latency, independent of US27 and US29 gene expression, using mutant viruses in hematopoietic cells.
DOI 10.3389/fcimb.2020.00186 - MicrobiologybioRxiv
Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency
E. G. Elder, B. A. Krishna, J. Williamson…·J. Sinclair
This study identifies that US28 downregulates interferon-inducible genes during HCMV latency, with IFI16 suppression enhancing viral gene expression via NF-κB.
DOI 10.1128/mbio.02574-19 - MicrobiologybioRxiv
The human cytomegalovirus G-protein coupled receptor US28 promotes latency by attenuating c-fos
B. A. Krishna, M. S. Humby, W. E. Miller, C. M. O'Connor
This paper shows that the HCMV-encoded US28 receptor promotes latency by reducing c-fos expression and AP-1 binding to the MIEP.
DOI 10.1073/pnas.1816933116