Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition
N. Thakur, A. Ray, L. Sharp, B. Jin, A. Duong, N. Gopal Pour, S. Obeng, A. Wijesekara, Z.-G. Gao, C. McCurdy, K. A. Jacobson, E. Lyman, M. Eddy
This study shows anionic lipids facilitate GPCR-G protein complex formation through conformational selection, with computational models supporting charge complementarity as a general mechanism.
bioRxiv · Jan 11, 2023Biophysics