BiophysicsNature CommunicationsPeer-reviewed
Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition
N. Thakur, A. Ray, L. Sharp…·M. Eddy
This study shows anionic lipids facilitate GPCR-G protein complex formation through conformational selection, with computational models supporting charge complementarity as a general mechanism.
DOI 10.1038/s41467-023-36425-z