Author

L. Sharp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:bacteria (other)· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Lyman· 2 shared A. Duong· 1 shared A. H. N. Nguyen· 1 shared A. Ray· 1 shared A. Tong· 1 shared A. Wijesekara· 1 shared B. Jin· 1 shared C. M. Nimigean· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

E. Lyman

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3 papers

Recent·Most cited

Varying the position of phospholipid acyl chain unsaturation modulates hopanoid and sterol ordering

A. H. N. Nguyen, L. Sharp, E. Lyman, J. P. Saenz

This study shows that hopanoids and sterols modulate lipid ordering differently based on phospholipid acyl chain unsaturation position, with cholesterol providing broader ordering effects than diplopterols.

bioRxiv · Sep 6, 2023Biophysics

Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition

N. Thakur, A. Ray, L. Sharp, B. Jin, A. Duong, N. Gopal Pour, S. Obeng, A. Wijesekara, Z.-G. Gao, C. McCurdy, K. A. Jacobson, E. Lyman, M. Eddy

This study shows anionic lipids facilitate GPCR-G protein complex formation through conformational selection, with computational models supporting charge complementarity as a general mechanism.

bioRxiv · Jan 11, 2023Biophysics

Direct Binding of Phosphatidylglycerol at Specific Sites Modulates Desensitization of a Pentameric Ligand-Gated Ion Channel

A. Tong, J. T. Petroff, F.-F. Hsu, P. A. Schmidpeter, C. M. Nimigean, L. Sharp, G. Brannigan, W. W. Cheng

The paper shows that phosphatidylglycerol binds to and stabilizes the pentameric ligand-gated ion channel ELIC, reducing desensitization.

bioRxiv · Aug 7, 2019Biophysics