Author

C. Pedebos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:mechanistic / dynamical model· 3 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1

Frequent Co-Authors

S. Khalid· 4 shared A. Boags· 2 shared A. Basle· 1 shared A. T. Shivgan· 1 shared B. van den Berg· 1 shared C. V. Robinson· 1 shared D. Abbas· 1 shared F. Samsudin· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

S. Khalid

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular architecture of the TasA biofilm scaffold in Bacillus subtilis

J. Boehning, M. Ghrayeb, C. Pedebos, D. Abbas, S. Khalid, L. Chai, T. Bharat

This study reveals the molecular structure of TasA biofilm scaffolds in Bacillus subtilis, showing they form β-sheet-rich filaments through donor strand complementation, essential for biofilm formation.

bioRxiv · Mar 14, 2022Microbiology

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

L. Zuzic, F. Samsudin, A. T. Shivgan, P. V. Raghuvamsi, J. K. Marzinek, A. Boags, C. Pedebos, N. K. Tulsian, J. Warwicker, P. MacAry, M. Crispin, S. Khalid, G. S. Anand, P. J. Bond

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

bioRxiv · May 5, 2021Biophysics

Structural basis for silicon uptake by higher plants

B. van den Berg, C. Pedebos, J. R. Bolla, C. V. Robinson, A. Basle, S. Khalid

This study presents the X-ray structure and molecular dynamics simulations of OsNIP2;1, revealing how silicon is taken up by plant roots through aquaporins.

bioRxiv · Apr 14, 2021Plant Biology

Assessment of Structural Units Deletions in the Archaeal Oligosaccharyltransferase AglB

C. Pedebos, H. Verli

This study evaluates the impact of structural unit deletions in the archaeal OST AglB using molecular modeling and dynamics simulations, showing effects on stability and dynamics but not catalysis.

bioRxiv · Aug 18, 2020 · PreprintBiophysics

The Hitchhiker's Guide to the Periplasm: Unexpected Molecular Interactions of Antibiotics Revealed by Considering Crowding Effects in E. coli

C. Pedebos, I. Smith, A. Boags, S. Khalid

This study uses molecular dynamics simulations to show that the antibiotic polymyxin B1 forms transient and long-lived interactions with periplasmic proteins and lipoproteins, suggesting it hitchhikes through the periplasm rather than diffusing freely.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry