Author

J. Warwicker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:structural biology· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. K. Marzinek· 3 shared L. Zuzic· 3 shared P. J. Bond· 3 shared A. Mazharian· 2 shared G. S. Anand· 2 shared K. Fütterer· 2 shared W. M. Abbott· 2 shared Y. A. Senis· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

J. K. Marzinek

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Author profile →

6 papers

Recent·Most cited

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

A. Mazharian, O. Bertin, A. Sarkar, J. Augros, A. Bornert, C. Loubiere, F. Jönsson, J. Warwicker, W. M. Abbott, O. Dushek, C. Vayne, L. Rauova, K. Fütterer, J. Rollin, M. Poncz, Y. A. Senis

This study introduces CAPRIs, bispecific antibodies that inhibit platelet activation by clustering G6B with ITAM receptors, showing effectiveness in preventing thrombus formation without causing bleeding.

bioRxiv · May 10, 2024 · PreprintCell Biology

Computational investigation of mechanisms for pH modulation of human chloride channels

K. Elverson, S. Freeman, F. Manson, J. Warwicker

This paper introduces a computational method to identify pH-sensitive amino acids in chloride channels by calculating pKas, validated across multiple proteins and applied to predict pH modulation in ion channel disorders.

bioRxiv · Oct 3, 2022Biophysics

A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

L. Zuzic, J. K. Marzinek, G. S. Anand, J. Warwicker, P. J. Bond

This paper identifies a pH-dependent charge cluster in flaviviral envelope proteins that influences domain dissociation and fusion through molecular dynamics simulations.

bioRxiv · Jul 12, 2022Biophysics

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

L. Zuzic, F. Samsudin, A. T. Shivgan, P. V. Raghuvamsi, J. K. Marzinek, A. Boags, C. Pedebos, N. K. Tulsian, J. Warwicker, P. MacAry, M. Crispin, S. Khalid, G. S. Anand, P. J. Bond

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

bioRxiv · May 5, 2021Biophysics

A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins

L. Zuzic, J. K. Marzinek, J. Warwicker, P. J. Bond

The paper introduces a benzene-mapping method using MD simulations to identify cryptic pockets in membrane-bound proteins, revealing a druggable pocket in the dengue virus E protein.

bioRxiv · Apr 4, 2020Biophysics

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

T. Vögtle, S. Sharma, J. Mori, Z. Nagy, D. Semeniak, M. J. Geer, C. W. Smith, J. Lane, S. Pollack, R. Lassila, A. Jouppila, A. J. Barr, D. J. Ogg, T. D. Howard, H. J. McMiken, , Y. A. Senis

This study identifies heparan sulfate as a critical regulator of G6b-B, showing it inhibits platelet and megakaryocyte function through Shp1/Shp2 signaling.

bioRxiv · Mar 25, 2019Biochemistry