Author

T. Bharat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Assay:cryo-EM· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:protein structure prediction· 2 Approach:Bayesian inference· 1 Organism:Drosophila· 1 Assay:electronic health records· 1

Frequent Co-Authors

J. Boehning· 3 shared A. von Kuegelgen· 2 shared S. van Dorst· 2 shared V. Alva· 2 shared A. K. Tarafder· 1 shared A. von Kügelgen· 1 shared C. Melia· 1 shared C. Pedebos· 1 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersMicrobiology

J. Boehning

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus

H. Ochner, J. Boehning, Z. Wang, A. K. Tarafder, I. Caspy, T. Bharat

This study reports the 3.2 Å resolution structure of the Pseudomonas aeruginosa PAO1 Type IV pilus using cryo-EM, revealing its architecture and potential functional roles.

bioRxiv · Apr 9, 2024 · PreprintMicrobiology

Interdigitated immunoglobulin arrays form the hyperstable surface layer of the extremophilic bacterium Deinococcus radiodurans

A. von Kuegelgen, S. van Dorst, K. Yamashita, D. L. Sexton, E. I. Tocheva, G. N. Murshudov, V. Alva, T. Bharat

This study reveals the structure of the hyperstable S-layer in Deinococcus radiodurans, showing it is formed by immunoglobulin-like HPI proteins arranged in a hexagonal lattice.

bioRxiv · Sep 15, 2022Microbiology

A multi-domain connector links the outer membrane and cell wall in deep-branching bacteria

A. von Kuegelgen, S. van Dorst, V. Alva, T. Bharat

This paper identifies a multi-domain connector protein in D. radiodurans that links the outer membrane to the cell wall, revealing its structural and evolutionary significance in bacterial envelope organization.

bioRxiv · May 18, 2022 · PreprintMicrobiology

Molecular architecture of the TasA biofilm scaffold in Bacillus subtilis

J. Boehning, M. Ghrayeb, C. Pedebos, D. Abbas, S. Khalid, L. Chai, T. Bharat

This study reveals the molecular structure of TasA biofilm scaffolds in Bacillus subtilis, showing they form β-sheet-rich filaments through donor strand complementation, essential for biofilm formation.

bioRxiv · Mar 14, 2022Microbiology

A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

J. Zivanov, J. Oton, Z. Ke, A. von Kügelgen, E. Pyle, K. Qu, D. Morado, D. Castano-Diez, G. Zanetti, T. Bharat, J. Briggs, S. Scheres

The paper introduces a Bayesian method for improving cryo-ET data analysis in RELION-4.0, enabling higher-resolution structure determination from multiple particles.

bioRxiv · Feb 28, 2022Biophysics

Architecture of cell-cell junctions in situ reveals a mechanism for bacterial biofilm inhibition

C. Melia, J. R. Bolla, S. Katharios-Lanwermeyer, D. Mihaylov, P. Hoffmann, J. Huo, M. Wozny, L. Elfari, J. Boehning, R. Owens, C. V. Robinson, G. O'Toole, T. Bharat

The paper reveals the structure and function of CdrA in Pseudomonas aeruginosa biofilms, showing how it mediates cell-cell interactions and how targeting it can inhibit biofilm formation.

bioRxiv · Feb 8, 2021Microbiology