Author

I. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Ecology· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Boags· 1 shared A. Johnson· 1 shared A. Nicolas· 1 shared A. T. Irving· 1 shared A. W. Morris· 1 shared B. Dupuis· 1 shared B. Haibe-Kains· 1 shared C. Pedebos· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Boags

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Eating an elephant, one bite at a time: predator interactions at carrion bonanzas

A. W. Morris, I. Smith, S. Chakrabarti, F. Lala, S. Nyagah, J. Bump

The paper studies predator interactions at elephant carcasses using remote cameras, finding interference competition among terrestrial predators and unique feeding behaviors at aquatic interfaces.

bioRxiv · Mar 31, 2023Ecology

Meta-analysis of preclinical pharmacogenomic studies to discover robust and translatable biomarkers of drug response

P. Smirnov, S. K. Nair, F. Abbas-Aghababazadeh, N. Feizi, I. Smith, T. J. Pugh, B. Haibe-Kains

This study identifies 4,338 statistically significant biomarkers of drug response across 8 tissue types and 34 drugs using meta-analysis of preclinical pharmacogenomic studies, with ODC1 showing clinical relevance for Paclitaxel response in breast cancer.

bioRxiv · Oct 22, 2022 · PreprintCancer Biology

The Hitchhiker's Guide to the Periplasm: Unexpected Molecular Interactions of Antibiotics Revealed by Considering Crowding Effects in E. coli

C. Pedebos, I. Smith, A. Boags, S. Khalid

This study uses molecular dynamics simulations to show that the antibiotic polymyxin B1 forms transient and long-lived interactions with periplasmic proteins and lipoproteins, suggesting it hitchhikes through the periplasm rather than diffusing freely.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry

Differential DNA methylation in the Vinv promoter region controls Cold Induced Sweetening in potato

L. Shumbe, M. Visse, E. Soares, I. Smith, B. Dupuis, H. Vanderschuren

The paper identifies differential DNA methylation in the Vinv promoter region as a mechanism controlling cold-induced sweetening in potato, showing hypermethylation in CIS-resistant varieties.

bioRxiv · Apr 26, 2020 · PreprintPlant Biology

Unique Evolution of Antiviral Tetherin in Bats

J. A. Hayward, M. Tachedjian, A. Johnson, A. T. Irving, T. B. Gordon, J. Cui, A. Nicolas, I. Smith, V. Boyd, G. A. Marsh, M. L. Baker, L.-F. Wang, G. Tachedjian

This study characterizes the evolution of tetherin in bats, identifying unique structural variants and splice isoforms with antiviral functions.

bioRxiv · Apr 8, 2020Evolutionary Biology