Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
J. Ding, S.-J. Lee, L. Vlahos, K. Yuki, C. Rada, V. van Unen, M. Vuppalapaty, H. Chen, A. Sura, A. McCormick, M. Tomaske, S. Alwahabi, H. Nguyen, W. Nowatzke, L. Kim, , C. Kuo
This study develops a bioengineered FZD4-selective WNT surrogate that improves BBB function and reduces ischemic stroke damage in mice.
bioRxiv · Oct 13, 2022 · PreprintPhysiology