Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
M. C. Hasselluhn, A. R. Decker-Farrell, L. Vlahos, D. H. Thomas, A. Curiel-Garcia, H. C. Maurer, U. N. Wasko, L. Tomassoni, S. A. Sastra, C. F. Palermo, T. C. Dalton, A. Ma, F. Li, E. J. Tolosa, H. Hibshoosh, , K. P. Olive
The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.
bioRxiv · Mar 2, 2023Cancer Biology