Author

C. Kuo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Physiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:imaging· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Approach:microscopy & imaging analysis· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

V. van Unen· 2 shared Y. Li· 2 shared A. Bhattacharya· 1 shared A. Califano· 1 shared A. J. Giaccia· 1 shared A. M. Hanash· 1 shared A. M. Trumbull· 1 shared A. McCormick· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPhysiology

V. van Unen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The colocatome as a spatial -omic reveals shared microenvironment features between tumour-stroma assembloids and lung cancer specimens

G. Bouchard, W. Zhang, I. Li, I. Ilerten, J. B. Shrager, A. Bhattacharya, Y. Li, W. Trope, M. G. Osawa, C. Kuo, L. Tian, A. J. Giaccia, S. K. Plevritis

The paper introduces the colocatome, a spatial-omic framework, to compare microenvironment features between tumour-stroma assembloids and lung cancer specimens, finding that fibroblasts protect cancer cells from treatment by reorganizing cytoarchitecture.

bioRxiv · Sep 11, 2023 · PreprintBioengineering

Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function

J. B. Sarthi, A. M. Trumbull, S. M. Abazari, V. van Unen, J. E. Chan, Y. Jiang, J. Gammons, M. O. Andrerson, O. Cil, C. Kuo, Z. M. Sellers

This study shows linaclotide stimulates bicarbonate secretion in CFTR-deficient tissues by enhancing DRA expression, suggesting DRA as a therapeutic target for CF-related intestinal dysfunction.

bioRxiv · May 5, 2023 · PreprintPhysiology

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

A. Sockell, W. Wong, S. Longwell, T. Vu, K. Karlsson, D. A. Mokhtari, J. Schaepe, Y.-H. Lo, V. Cornelius, C. Kuo, D. A. Van Valen, C. Curtis, P. M. Fordyce

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

bioRxiv · Nov 1, 2022Bioengineering

Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate

J. Ding, S.-J. Lee, L. Vlahos, K. Yuki, C. Rada, V. van Unen, M. Vuppalapaty, H. Chen, A. Sura, A. McCormick, M. Tomaske, S. Alwahabi, H. Nguyen, W. Nowatzke, L. Kim, , C. Kuo

This study develops a bioengineered FZD4-selective WNT surrogate that improves BBB function and reduces ischemic stroke damage in mice.

bioRxiv · Oct 13, 2022 · PreprintPhysiology

High-resolution positron emission microscopy of patient-derived tumor organoids

S. Khan, J. H. Shin, V. Ferri, N. Cheng, J. E. Noel, C. Kuo, J. B. Sunwoo, G. Pratx

This paper develops a high-resolution microscopy method to image FDG in tumor organoids, mirroring clinical PET scans and predicting treatment response.

bioRxiv · Jul 28, 2020Cancer Biology

A Holistic Analysis of the Intestinal Stem Cell Niche Network

D. M. Hansen, P. I. Meneses Giles, X. C. He, S. Chen, A. Paulson, C. M. Dekaney, J. Wang, D. Hu, A. Venkatraman, W. Kim, J. Kaddis, B. J. Olack, J. C. Y. Dunn, C. Kuo, S. Henning, , L. Li

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

bioRxiv · Dec 12, 2019 · PreprintCell Biology

Comparison of video-based and sensor-based head impact exposure

C. Kuo, L. C. Wu, J. Loza, D. Senif, S. Anderson, D. B. Camarillo

This study compares video-based and sensor-based methods for quantifying head impact exposure in American football, finding they complement each other but have limitations.

bioRxiv · Mar 19, 2018Bioengineering