Author

C. Roca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Dashwood· 1 shared A. de Boer· 1 shared A. Garcia-Rubia· 1 shared A. Kerstens· 1 shared A. Liston· 1 shared A. M. Gomez Pozo· 1 shared A. Martinez· 1 shared A. Quijada-Freire· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

A. Dashwood

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

M. A. Greenwald, S. L. Meinig, L. M. Plott, C. Roca, M. G. Higgs, N. P. Vitko, M. R. Markovetz, K. R. Rouillard, J. Carpenter, M. Kesimer, D. B. Hill, J. C. Schisler, M. C. Wolfgang

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

bioRxiv · Dec 20, 2023 · PreprintMicrobiology

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

E. M. Garcia-Cuesta, P. Martinez, K. Selvaraju, G. Ulltjärn, A. M. Gomez Pozo, G. D'Agostino, S. Gardeta, A. Quijada-Freire, P. Blanco Gabella, C. Roca, D. del Hoyo, R. Jimenez-Saiz, A. Garcia-Rubia, B. Soler Palacios, P. Lucas, , M. Mellado

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

bioRxiv · Nov 19, 2023Cell Biology

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

bioRxiv · Feb 28, 2022Immunology