Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
E. M. Garcia-Cuesta, P. Martinez, K. Selvaraju…·M. Mellado
This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.