W. Feng

Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

This study introduces a point mutation in MLL1 in iPS cells to mimic MLL1F-LSCs phenotypes, revealing that loss of MLL1 enzymatic activity drives H3K4 trimethylation via mislocalized SETd1a.

CAMSAP3 Forms Dimers via its lapha-helix Domain that Directly Stabilize Non-centrosomal Microtubule Minus Ends

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

Phase Contrast Tomography (PCT)

This paper introduces phase contrast tomography (PCT) for 3D phase imaging, demonstrating its high resolution and stability for imaging microspheres and sub-organelles.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

The alpha4 nicotinic acetylcholine receptor is necessary for the initiation of organophosphate-induced neuronal hyperexcitability

This study shows that alpha4 nicotinic acetylcholine receptors are required for organophosphate-induced neuronal hyperexcitability in vitro and in vivo.

Rim4 is a Meiotic Thermal Sensor and Drives Biogenesis of Stress Granules

This paper identifies Rim4 as a meiotic thermal sensor that forms reversible condensates triggered by heat, promoting stress granule assembly and protecting meiotic processes from thermal stress.

Pathogen and host adapt pH responses during enteric infection

This study examines how enteric pathogens and their hosts adapt to different pH environments during infection, revealing pH-dependent virulence and host defense mechanisms.

Cross-platform comparison of highly-sensitive immunoassays for inflammatory markers in a COVID-19 cohort

This study compares three immunoassay platforms for inflammatory markers in a COVID-19 cohort, finding differences in detectability, correlation, and differential expression.

Multilevel regulation of NF-kappa B signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

Promotion of tumor angiogenesis and growth induced by low-dose antineoplastic agents via bone-marrow-derived cells

This study investigates low-dose antineoplastic agents' effects on tumor growth and angiogenesis via bone-marrow-derived cells in mouse models.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

Plant selection and ecological microhabitat drive domestications of shrub-associated microbiomes in a revegetated shrub ecosystem

This study examines how plant selection and ecological microhabitats influence the microbiomes of revegetated shrubs, finding that microhabitats, not plant species, primarily drive microbial community composition.

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

Cdc14 spatiotemporally regulates Rim4-mRNA complex assembly and stability during meiosis

This study identifies Cdc14's role in regulating Rim4-mRNA complex assembly and stability during meiosis through phosphorylation and spatial dynamics.

Autophagy inspects Rim4-mRNA interaction to safeguard programmed meiotic translation

The paper shows autophagy selectively degrades Rim4 during meiosis, sparing bound mRNAs for programmed translation.

Soil depth governs microbial community assembly and enzymatic activity in extreme environments

The paper examines how soil depth influences microbial community structure and enzymatic activity in extreme desert environments, finding that depth-related environmental heterogeneity drives these patterns.

FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase

The paper was withdrawn due to duplicate submission and is not intended for citation.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

Allosteric interactions prime androgen receptor dimerization and activation

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

Intracranial Electric Field Recording During Multichannel Transcranial Electrical Stimulation

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

Cdc14 activates autophagy to regulate spindle pole body dynamics during meiosis

This study identifies Cdc14 as a meiosis-specific autophagy regulator that controls spindle pole body dynamics by dephosphorylating Atg13 and promoting autophagy during anaphase I and II.

Structures of the human cholecystokinin receptors in complex with agonists and antagonists

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

LIN37-DREAM Prevents DNA End Resection and Homologous Recombination at DNA Double Strand Breaks in Quiescent Cells

The paper shows LIN37 prevents DNA end resection and HR in quiescent cells independently of 53BP1, unlike in cycling cells.

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

This study shows FMRP directly binds R-loops and inhibits DHX9 helicase activity, preventing R-loop accumulation and genome instability in FXS.

Changes and composition of microbial community during aerobic composting of household food waste

This study compares microbial communities in natural and bacteria-added composting of household food waste, finding that different dominant bacteria influence degradation rates and odor removal.

A water-reward task assay for evaluating mouse mutualistic cooperative behavior

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

Effects of Ca2+ on encystment and growth in Scrippsiella trochoidea

This study examines how varying calcium concentrations affect the growth and encystment of Scrippsiella trochoidea, finding increased cell density and cyst formation at lower calcium levels, with reductions at higher concentrations.