Author

C. Sawyers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

W. Feng· 2 shared W. Karthaus· 2 shared A. Gopalan· 1 shared A. Vanden Broeck· 1 shared B. S. Carver· 1 shared B. Wang· 1 shared C. S. Leslie· 1 shared D. Matthies· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

W. Feng

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

W. Feng, E. Ladewig, N. Salsabeel, H. Zhao, Y. S. Lee, A. Gopalan, M. Lange, H. Luo, W. Kang, N. Fan, E. Rosiek, E. De Stanchina, Y. Chen, B. S. Carver, C. S. Leslie, C. Sawyers

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

bioRxiv · May 15, 2023Cancer Biology

Allosteric interactions prime androgen receptor dimerization and activation

E. Wasmuth, A. Vanden Broeck, J. R. LaClair, E. A. Hoover, K. E. Lawrence, N. Paknejad, K. J. Pappas, D. Matthies, B. Wang, W. Feng, P. A. Watson, J. C. Zinder, W. Karthaus, M. J. de la Cruz, R. K. Hite, , C. Sawyers

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

bioRxiv · Feb 20, 2022Biochemistry

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

W. Karthaus, J. Chan, M. Setty, J. Love, S. Zaidi, Z.-N. Choo, S. Persad, J. LaClair, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, D. Pe'er, C. Sawyers

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology