Author

C. Savva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:cryo-EM· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

M. Korach-Andre· 3 shared D. Couto· 2 shared M. R. Domingues· 2 shared T. Melo· 2 shared X. Li· 2 shared A. Archer· 1 shared A. D. Cameron· 1 shared A. De Biasio· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

M. Korach-Andre

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Author profile →

5 papers

Recent·Most cited

Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner

C. Savva, L. A. Helguero, M. Gonzalez-Granillo, T. Melo, D. Couto, B. Angelin, M. R. Domingues, X. Li, C. Kutter, M. Korach-Andre

The paper examines sex-specific metabolic differences in offspring of obese mothers, showing females have better metabolic outcomes due to more efficient transcriptional and posttranscriptional reprogramming.

bioRxiv · May 26, 2021Physiology

Maternal obesity programs white and brown adipose tissue transcriptome and lipidome in offspring in a sex-dependent manner

C. Savva, L. Helguero, M. Gonzalez-Garnillo, T. Melo, d. couto, B. Buyandelger, S. Gustafsson, J. Liu, M. R. Domingues, X. Li, M. Korach-Andre

This study shows maternal obesity differentially programs gene expression in adipose tissues of male and female offspring, contributing to sex-dependent metabolic complications.

bioRxiv · Feb 8, 2021Cell Biology

Conformational changes and channel gating induced by CO2 binding to Connexin26

D. H. Brotherton, C. Savva, T. Ragan, V. Linthwaite, M. Cann, N. Dale, A. D. Cameron

This study shows CO2 directly affects Connexin26 gap junctions by inducing conformational changes that regulate channel gating.

bioRxiv · Aug 11, 2020 · PreprintBiochemistry

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogens

L. Hases, A. Archer, R. Indukuri, M. Birgersson, C. Savva, M. Korach-Andre, C. Williams

This study shows that high-fat diet affects the colon transcriptome differently in males and females, with estrogen modulating these effects through specific receptors.

bioRxiv · Jun 3, 2020Cell Biology

Structure of the processive human Pol δ holoenzyme

C. Lancey, M. Tehseen, V.-S. Raducanu, F. Rashid, N. Merino, T. J. Ragan, C. Savva, M. S. Zaher, A. Shirbini, F. J. Blanco, S. M. Hamdan, A. De Biasio

This study presents the high-resolution cryo-EM structure of the human Pol δ-DNA-PCNA complex with and without FEN1, revealing its structural basis for DNA replication.

bioRxiv · Dec 11, 2019Biochemistry