Cancer BiologybioRxiv
1,4-dihydroxy Quininib Attenuates Growth of Colorectal Cancer Cells and Xenografts and Regulates the TIE-2 Signaling Pathway in Patient Tumours
C. T. Butler, S. Kennedy, A. Buckley…·B. N. Kennedy
This study shows that Q8, a modified quininib, inhibits colorectal cancer growth and angiogenesis by targeting the TIE-2 signaling pathway in both cell and xenograft models.