Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway
R. C. S. Edgar, G. Siddiqui, K. Hjerrild, T. R. Malcolm, N. B. Vinh, C. T. Webb, C. A. MacRaild, N. A. Counihan, D. J. Creek, P. J. Scammels, S. McGowan, T. F. De Koning-Ward
This study validates PfA-M17 as a novel drug target by showing its essential role in Plasmodium falciparum survival and demonstrating the efficacy of a specific inhibitor.
bioRxiv · Nov 23, 2021Microbiology