X. Lai

SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development

The paper shows that SEPALLATA-driven MADS tetramerization is essential for inner whorl floral organ identity, beyond its role in meristem determinacy.

Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

Mechanism of treatment-free remission in patients with chronic myeloid leukemia revealed by a computational model of CML evolution

The paper develops a computational model to study the mechanisms of treatment-free remission in CML patients, revealing the role of the neoplastic microenvironment and leukemia stem cell dynamics.

Inhibition of SAR S-CoV-2 infection and replication by lactoferrin, MUC1 and α-lactalbumin identified in human breastmilk

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity

The paper identifies an additional signal in bacterial outer membrane proteins that enhances assembly efficiency and maintains membrane integrity through interaction with BamD.

The Intervening Domain Is Required For DNA-binding and Functional Identity of Plant MADS Transcription Factors

This study shows the Intervening domain is essential for DNA-binding and functional identity of plant MADS transcription factors through structural and functional analyses.

Unraveling the role of MADS transcription factor complexes in apple tree dormancy using sequential DAP-seq

This study identifies MADS TF complexes regulating apple tree dormancy using seq-DAP-seq and transcriptomics, revealing a gene regulatory network and evolutionary insights.

The LEAFY floral regulator displays pioneer transcription factor properties

This study shows that LEAFY, a floral regulator in Arabidopsis, binds both methylated and non-methylated DNA and can induce chromatin accessibility in target genes.

SARS-CoV-2 and Malayan pangolin coronavirus infect human endoderm, ectoderm and induced lung progenitor cells

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

Lions and brown bears colonized North America in multiple synchronous waves of dispersal across the Bering Land Bridge

This study analyzes mitochondrial genomes of ancient brown bears and lions to show synchronous dispersal and extinction events across the Bering Land Bridge during the Pleistocene.

Molecular mechanisms of Evening Complex activity in Arabidopsis

This paper identifies the molecular mechanisms of the Evening Complex (EC) in Arabidopsis, showing how ELF3 and ELF4 modulate LUX DNA binding and demonstrating structure-based engineering of a modified LUX allele that alters plant growth.

Co-Expression Network-based Analysis associated with potato initial resistance

The paper constructs a gene co-expression network for potato using RNA-seq data to identify gene modules associated with disease and stress resistance in a native cultivar.

Niacin fine-tunes energy homeostasis through canonical GPR109A signaling

This study shows niacin reduces body weight and fat mass via GPR109A-dependent pathways, improving energy homeostasis in mice.

Parallel natural selection in the cold-adapted crop-wild relative Tripsacum dactyloides and artificial selection in temperate adapted maize

The paper identifies overlapping genetic targets of natural and artificial selection in Tripsacum dactyloides and maize for temperate adaptation.

Towards personalized computer simulation of breast cancer treatment: a multi-scale pharmacokinetic and pharmacodynamic model informed by multi-type patient data

This study develops a multi-scale pharmacokinetic and pharmacodynamic model of breast cancer treatment, personalized with patient data to simulate and improve treatment outcomes.

Largely unlinked gene sets targeted by selection for domestication syndrome phenotypes in maize and sorghum

The paper examines whether artificial selection for domestication traits in maize and sorghum targets orthologous genes, finding that while some genes show parallel selection, most targeted genes are non-overlapping.