Author

C. Toelzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Schaffitzel· 2 shared D. Fitzgerald· 2 shared F. Garzoni· 2 shared I. Berger· 2 shared K. Gupta· 2 shared U. Borucu· 2 shared A. Cabrera-Orefice· 1 shared A. D. Davidson· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

C. Schaffitzel

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Author profile →

3 papers

Recent·Most cited

Pentameric assembly of glycine receptor intracellular domains provides insights into gephyrin clustering

A. Macha, N. Gruenewald, N. Havarushka, N. Burdina, C. Toelzer, Y. Merkler, A. Cabrera-Orefice, T. Pauly, U. Brandt, L. Nagel-Steger, K. Niefind, G. Schwarz

The paper studies glycine receptor intracellular domains using a pentameric scaffold, revealing structural flexibility and a mechanism for gephyrin clustering at inhibitory synapses.

bioRxiv · Nov 10, 2022 · PreprintBiochemistry

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

C. Toelzer, K. Gupta, S. K. N. Yadav, L. Hodgson, M. Kavanagh Williamson, D. Buzas, U. Borucu, K. Powers, R. Stenner, K. Vasileiou, F. Garzoni, D. Fitzgerald, C. Payre, G. Lambeau, A. D. Davidson, , C. Schaffitzel

The paper identifies a conserved free fatty acid-binding pocket in pathogenic β-coronavirus spike proteins that suppresses viral infection and replication.

bioRxiv · Apr 22, 2022Biochemistry

Unexpected free fatty acid binding pocket in the cryo-EM structure of SARS-CoV-2 spike protein

C. Toelzer, K. Gupta, S. K. Yadav, U. Borucu, F. Garzoni, O. Staufer, J. Capin, J. Spatz, D. Fitzgerald, I. Berger, C. Schaffitzel

The paper reveals a direct structural link between SARS-CoV-2 spike protein and linoleic acid, a key molecule in inflammation, immune modulation, and membrane fluidity.

bioRxiv · Jun 18, 2020Biochemistry