I. Berger

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

This paper uses D-NEMD simulations to study how the fatty acid site in the glycosylated SARS-CoV-2 spike modulates its structure and function, revealing allosteric networks and the role of glycans.

FRET-based sensor for measuring adenine nucleotide binding to AMPK

The paper describes an AMPK-based FRET sensor, AMPfret, that detects conformational changes in AMPK upon nucleotide binding, enabling analysis of AMPK activation in vitro and in cells.

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Molecular dynamics of spike variants in the locked conformation: RBD interfaces, fatty acid binding and furin cleavage sites.

This study uses molecular dynamics simulations to analyze sequence variations in SARS-CoV-2 spike proteins and their effects on receptor binding domain interfaces, fatty acid binding, and furin cleavage site motions across variants.

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

The paper identifies a conserved free fatty acid-binding pocket in pathogenic β-coronavirus spike proteins that suppresses viral infection and replication.

SARS-CoV-2 spike variants differ in their allosteric response to linoleic acid

This study compares how SARS-CoV-2 spike variants respond to linoleic acid removal using simulations, finding significant differences in allosteric connections that may affect transmissibility and virulence.

The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour

This study uses molecular dynamics simulations to show that the fatty acid binding site in the SARS-CoV-2 spike protein influences distant functional regions and variant behavior.

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.

Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety

This study shows chronic oxytocin increases soluble CRFR2, linked to anxiety, while acute oxytocin reduces anxiety via membrane-bound CRFR2.

Unexpected free fatty acid binding pocket in the cryo-EM structure of SARS-CoV-2 spike protein

The paper reveals a direct structural link between SARS-CoV-2 spike protein and linoleic acid, a key molecule in inflammation, immune modulation, and membrane fluidity.

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

Ecological and dietary differences between Ugandan chimpanzee communities with possible implications on tool use

This study compares ecological and dietary differences between Ugandan chimpanzee communities to explore their implications on tool use, finding that Sonso chimpanzees have higher food diversity but lower stick and insect nest availability, potentially explaining their limited tool use.

Sequential digestion with Trypsin and Elastase in cross-linking/mass spectrometry

The paper introduces a sequential digestion method using trypsin and elastase to improve cross-linking/mass spectrometry analysis of protein complexes by accessing previously inaccessible regions.

Architecture of TAF11/TAF13/TBP complex suggests novel regulatory state in General Transcription Factor TFIID function

The paper identifies a ternary TAF11/TAF13/TBP complex and reveals a novel regulatory state in TFIID function through structural and biochemical analyses.