Author

U. Borucu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Approach:deep learning· 1

Frequent Co-Authors

C. Schaffitzel· 5 shared I. Berger· 4 shared F. Garzoni· 3 shared J. Mantell· 3 shared K. Gupta· 3 shared P. Verkade· 3 shared C. Toelzer· 2 shared D. Buzas· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersBiochemistry

C. Schaffitzel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

CryoET reveals actin filaments within platelet microtubules

C. Tsuji, M. Bradshaw, M. Allen, M. L. Jackson, J. Mantell, U. Borucu, A. W. Poole, P. Verkade, I. Hers, D. M. Paul, M. Dodding

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.

bioRxiv · Nov 24, 2023Cell Biology

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

D. Buzas, H. A. Bunzel, O. Staufer, E. Milodowski, G. Edmonds, J. Bufton, B. Vidana Matteo, S. Yadav, K. Gupta, C. Fletcher, M. Kavanagh Williamson, A. Harrison, U. Borucu, J. Capin, O. Francis, , I. Berger

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

bioRxiv · Mar 17, 2023Biochemistry

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

M. Healy, K. McNally, R. Butkovic, M. Chilton, K. Kato, J. Sacharz, C. McConville, E. Moody, S. Shaw, V. Planelles-Herrero, S. Yadav, J. Ross, U. Borucu, C. Palmer, K.-E. Chen, , P. Cullen

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

Molecular architecture of the autoinhibited kinesin-1 lambda particle

J. F. Weijman, S. Y. Kadapalakere, K. J. Surridge, J. A. Cross, U. Borucu, J. Mantell, D. N. Woolfson, C. Schaffitzel, M. P. Dodding

The paper integrates computational structure prediction with electron microscopy to reveal the coiled-coil architecture of the autoinhibited compact form of kinesin-1.

bioRxiv · Apr 28, 2022Cell Biology

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

C. Toelzer, K. Gupta, S. K. N. Yadav, L. Hodgson, M. Kavanagh Williamson, D. Buzas, U. Borucu, K. Powers, R. Stenner, K. Vasileiou, F. Garzoni, D. Fitzgerald, C. Payre, G. Lambeau, A. D. Davidson, , C. Schaffitzel

The paper identifies a conserved free fatty acid-binding pocket in pathogenic β-coronavirus spike proteins that suppresses viral infection and replication.

bioRxiv · Apr 22, 2022Biochemistry

Unexpected free fatty acid binding pocket in the cryo-EM structure of SARS-CoV-2 spike protein

C. Toelzer, K. Gupta, S. K. Yadav, U. Borucu, F. Garzoni, O. Staufer, J. Capin, J. Spatz, D. Fitzgerald, I. Berger, C. Schaffitzel

The paper reveals a direct structural link between SARS-CoV-2 spike protein and linoleic acid, a key molecule in inflammation, immune modulation, and membrane fluidity.

bioRxiv · Jun 18, 2020Biochemistry

In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen

D. M. Paul, J. Mantell, U. Borucu, J. Coombs, K. J. Surridge, J. M. Squire, P. Verkade, M. P. Dodding

The paper uses cryo-electron tomography to show F-actin within microtubule lumens in induced cellular projections, revealing new cytoskeletal configurations.

bioRxiv · Nov 18, 2019Cell Biology