ImmunologyNature CommunicationsPeer-reviewed
Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation
G. Zhao, M. E. Gentile, L. Xue…·A. E. Vaughan
This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.
DOI 10.1038/s41467-024-48589-3