G. Zhao

The tubule-sheet continuum model links the pattern of nuclear envelope assembly to nuclear envelope integrity

The paper shows that cancer cells use a NE assembly pattern linked to fragility, differing from normal cells.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Disruption of Immune Responses By Type I Diabetes Exacerbates SARS-CoV-2 Mediated Lung Injury

This study shows that Type I Diabetes Mellitus worsens SARS-CoV-2-induced lung injury in mice by impairing immune responses and increasing inflammation.

Molecular stratification of human fetal vaginal epithelium by spatial transcriptome analysis

This study uses spatial transcriptomics to classify human fetal vaginal epithelium into four zones, identifying distinct gene expression patterns and potential differentiation trajectories.

CyanoTag: Discovery of protein function facilitated by high-throughput endogenous tagging in a photosynthetic prokaryote

The paper introduces CyanoTag, a high-throughput method for endogenous fluorescent protein tagging in Synechococcus elongatus, enabling subcellular localization, protein abundance tracking, and interaction network analysis of over 330 proteins.

Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA

This study shows bacterial ExoIII can cleave single-stranded DNA (ssDNA) via exonuclease and endonuclease activities, revealing new enzymatic functions and implications for biosensor design.

Changes in physicochemical properties and microbial community succession during leaf stacking fermentation

This study examines changes in physicochemical properties and microbial communities during leaf stacking fermentation, identifying key metabolites and microbial interactions.

Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic niche

The paper shows that mechanotransduction via TAZ and cytoskeletal tension promotes prostate cancer stem cell metastasis and identifies a YAP/TAZ inhibitor as a potential therapeutic target.

Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer

This study shows that targeting both AMPK and mTOR can inhibit prostate cancer metastasis by blocking the metabolic switch required for tumor growth in new environments.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation

This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.

Ferroptosis induced by phenolic compound-iron complex

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

Remodeling the central metabolism of Escherichia coli enables a universal chassis

This paper describes the construction of an E. coli strain with suppressed overflow metabolism, leading to improved chemical and protein production.

A COVID-19 DNA Vaccine Candidate Elicits Broadly Neutralizing Antibodies Against Multiple SARS-CoV-2 Variants Including the Currently Circulating Omicron BF.5, BF.7, BQ.1 and XBB

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

This study shows that stabilizing neutrophil extracellular traps (NETs) with platelet factor 4 reduces thrombogenicity and endothelial cell injury in sepsis.

Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.

Revealing the structure of somatic cell membranes by in situ cryo-electron tomography

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of 293T cell membranes, showing lipid bilayer thickness and protein distribution.

ZetaSuite, A Computational Method for Analyzing Multi-dimensional High-throughput Data, Reveals Genes with Opposite Roles in Cancer Dependency

ZetaSuite analyzes multi-dimensional high-throughput data to identify genes with opposite roles in cancer dependency, revealing key genes in DNA replication/repair checkpoint.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

The Balance between Saturated and Unsaturated Fatty Acids Regulates Ovarian Cancer Cell Fate

This study shows that the balance between saturated and unsaturated fatty acids, regulated by SCD, affects ovarian cancer cell survival and tumor progression, with UFAs protecting against ER stress-induced apoptosis.

Hinokitiol alters Gene Expression in Aspergillus fumigatus, protects against fungal keratitis by Reducing Fungal Load, LOX-1, Proinflammatory cytokines and Neutrophil Infiltration

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

The high-resolution structure of cell membranes revealed by in situ cryo-electron tomography

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of human red blood cell membranes and their protein distribution.

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy.

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

Multi-Functionalized Self-Bonding MXene for Minimal-invasive Jet-injected Neural Interface and Tissue Healing

The paper develops a minimal-invasive neural interface using MXene nanosheets to promote nerve regeneration and electrophysiology recording in mice.

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

MiR-384 Regulates Reelin by Inhibiting ADAMTS4 in Neuronal Cell Lines

The paper investigates miR-384's role in regulating Reelin by inhibiting ADAMTS4 in neuronal cell lines, showing reduced ADAMTS4 and Reelin fragments with miR-384 overexpression.

Metabolic Reprogramming from Glycolysis to Fatty Acid Uptake and beta-Oxidation in Platinum-Resistant Cancer Cells

The paper identifies metabolic reprogramming in platinum-resistant cancer cells from glycolysis to fatty acid uptake and beta-oxidation, showing a correlation with resistance and proposing a treatment strategy.