Author

B. M. Lorton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 3 Approach:biophysical modeling· 2 Organism:C. elegans· 1 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Assay:structural biology· 1 Organism:Xenopus· 1

Frequent Co-Authors

D. Shechter· 3 shared A. Biswas· 1 shared A. Fiser· 1 shared C. Hoege· 1 shared C. Warren· 1 shared D. Cowburn· 1 shared D. Hunt· 1 shared E. S. Burgos· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

D. Shechter

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3 papers

Recent·Most cited

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency

B. M. Lorton, C. Warren, H. Ilyas, P. Nandigrami, S. Hegde, S. Cahill, S. M. Lehman, J. Shabanowitz, D. Hunt, A. Fiser, D. Cowburn, D. Shechter

The paper shows that glutamylation of acidic IDRs in Npm2 and Nap1 enhances their DNA mimicry function, improving histone chaperone efficiency in nucleosome assembly.

bioRxiv · Sep 18, 2023Biochemistry

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes

A. Biswas, O. Munoz, K. Kim, C. Hoege, B. M. Lorton, D. Shechter, J. Guck, V. Zaburdaev, S. Reber

This study shows that the nuclear-to-cytoplasmic density ratio is conserved across eukaryotes and drives cellular organization, with implications for diseases like cancer and senescence.

bioRxiv · Sep 5, 2023Biophysics

A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5

B. M. Lorton, R. K. Harijan, E. S. Burgos, J. B. Bonnano, S. C. Almo, D. Shechter

The paper investigates how arginine methylation states of H3R2 regulate its interaction with WDR5, revealing a binary switch mechanism where me2a blocks binding while me0/me1/me2s allow it.

bioRxiv · Jan 13, 2020Biochemistry