Author

D. Shechter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Approach:biophysical modeling· 2 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. M. Lorton· 3 shared A. D. Casill· 2 shared C. C. Query· 2 shared C. Warren· 2 shared E. S. Burgos· 2 shared M. I. Maron· 2 shared M. J. Gamble· 2 shared S. C. Almo· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

B. M. Lorton

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

M. Venkatasubramanian, L. Schwartz, N. Ramachandra, J. Bennett, K. R. Subramanian, S. Gordon-Mitchell, A. Fromowitz, K. Pradhan, D. Shechter, S. Sahu, D. Heiser, P. Scherle, X. Chen, C. Chetal, A. Kulkarni, , N. G. Salomonis

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

bioRxiv · Feb 4, 2024Cancer Biology

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency

B. M. Lorton, C. Warren, H. Ilyas, P. Nandigrami, S. Hegde, S. Cahill, S. M. Lehman, J. Shabanowitz, D. Hunt, A. Fiser, D. Cowburn, D. Shechter

The paper shows that glutamylation of acidic IDRs in Npm2 and Nap1 enhances their DNA mimicry function, improving histone chaperone efficiency in nucleosome assembly.

bioRxiv · Sep 18, 2023Biochemistry

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes

A. Biswas, O. Munoz, K. Kim, C. Hoege, B. M. Lorton, D. Shechter, J. Guck, V. Zaburdaev, S. Reber

This study shows that the nuclear-to-cytoplasmic density ratio is conserved across eukaryotes and drives cellular organization, with implications for diseases like cancer and senescence.

bioRxiv · Sep 5, 2023Biophysics

Type I PRMTs and PRMT5 Inversely Regulate Post-Transcriptional Intron Detention

M. I. Maron, A. D. Casill, V. Gupta, S. Sidoli, C. C. Query, M. J. Gamble, D. Shechter

This study shows PRMTs inversely regulate intron retention post-transcriptionally through arginine methylation of Sm and CHTOP proteins.

bioRxiv · Aug 20, 2021Cancer Biology

Type I PRMTs and PRMT5 Independently Regulate Both snRNP Arginine Methylation and Post-Transcriptional Splicing

M. I. Maron, E. S. Burgos, V. Gupta, A. D. Casill, B. Kosmyna, H. Chen, M. J. Gamble, C. C. Query, D. Shechter

The paper investigates how Type I PRMTs and PRMT5 regulate splicing by analyzing transcriptomic changes and co-transcriptional splicing kinetics.

bioRxiv · Nov 18, 2020 · PreprintCell Biology

Structure of a Single Chain H2A/H2B Dimer

C. Warren, J. B. Bonanno, S. C. Almo, D. Shechter

The paper creates a single-chain H2A/H2B dimer and determines its structure, showing it resembles nucleosomal H2A/H2B, providing a tool for studying H2A/H2B-interacting proteins.

bioRxiv · Mar 15, 2020Biochemistry

A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5

B. M. Lorton, R. K. Harijan, E. S. Burgos, J. B. Bonnano, S. C. Almo, D. Shechter

The paper investigates how arginine methylation states of H3R2 regulate its interaction with WDR5, revealing a binary switch mechanism where me2a blocks binding while me0/me1/me2s allow it.

bioRxiv · Jan 13, 2020Biochemistry