Cancer BiologybioRxiv
PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
F. Wiede, K.-H. Lu, X. Du…·T. Tiganis
This study identifies PTP1B as an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity, showing its deletion or inhibition enhances tumor suppression.
DOI 10.1158/2159-8290.cd-21-0694