Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
C.-C. Tang, C. Castro, M. J. O'Meara, S.-H. Yoon, D. J. Brooks, M. L. Bouxsein, J. d. S. Martins, J. Wang, N. S. Gray, B. Misof, P. Roschger, S. Boulin, K. Klaushofer, A. Velduis-Vlug, Y. Vegting, , M. N. Wein
The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.
bioRxiv · Feb 26, 2021Physiology