C. J. Rosen

This study shows that irisin deletion affects murine osteocyte function differently in males and females, with protection in females under calcium deficiency and increased bone loss in males.

This paper develops Fshr-ZsGreen knockin reporter mice to study FSHR expression in vivo, revealing novel extragonadal expression patterns and expanding the known physiological roles of the FSH-FSHR pathway.

This paper develops a stable, high-concentration formulation of a humanized FSH-blocking antibody and validates its physicochemical and thermal stability.

This study shows that PTH regulates bone formation by suppressing Zfp467 through cyclic AMP/PKA pathway, enhancing Pth1r transcription and osteogenesis.

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

This study shows Maf1 regulates bone mass by modulating RNA polymerase III transcription, with both loss and gain of function leading to high bone mass, but through distinct mechanisms.

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.

This study shows that PHOSPHO1 deficiency improves glucose homeostasis and protects against obesity and diabetes without altering osteocalcin levels.