Parkin coordinates mitochondrial lipid remodeling to execute mitophagy
C.-C. Lin, J. Yan, M. D. Kapur, K. L. Norris, C.-W. Hsieh, C.-H. Lai, N. Vitale, K.-L. Lim, Z. Guan, J.-T. Chi, W.-Y. Yang, T.-P. Yao
This study shows Parkin orchestrates mitochondrial lipid remodeling through phospholipase D2 and Lipin-1 to drive mitophagy via DAG production and autophagosome formation.
bioRxiv · Feb 28, 2020Cell Biology