Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy
Fatima Abrar, Martyn C. Davies, A. Kumar, A. Dang, Yvonne Nguyen, Jennifer A. Collins, Nicholas S. Caron, J.S. Choudhary, Shaun S. Sanders, Mark O. Collins, Michael R. Hayden, Dale D. O. Martin
The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.
bioRxiv · Oct 11, 2023 · PreprintNeuroscience