D. He

Reversible kink instability drives ultrafast jumping in nematodes and soft robots

This paper demonstrates that a reversible kink instability in nematodes enhances jumping performance and proposes a bio-inspired model for soft robots.

Phase-separating MoSpa2 Complex Organizes Actin Nucleation Center for M.oryzae Plant Infection

This study identifies MoSpa2's role in organizing actin nucleation centers in Magnaporthe oryzae through phase separation, supporting polarized growth and host infection.

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Single-cell analysis characterizes PLK1 as a catalyst of an immunosuppressive tumor microenvironment in LUAD

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

The paper determines the structure of the SIT1 proline transporter complexed with ACE2 using cryo-EM, revealing substrate specificity and structural changes related to transport and a disease-causing mutation.

Selenoprotein synthesis is not induced by hepatotoxic drugs

This study investigates whether hepatotoxic drugs induce selenoprotein synthesis and finds that they do not, instead causing inhibition of both selenoprotein and general protein synthesis.

Cryo-EM complex structure of active GPR75 with a nanobody

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

The cardiac STAT3 intercalated disc specific expression in tail suspension rat

This study examines right ventricle remodeling in tail-suspended rats under microgravity simulation, finding STAT3 accumulation and gap junction remodeling without significant hypertrophy.

CNS antigen-specific control of early B-lineage development in the meninges

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

BoolSim, a Graphical Interface for Open Access Boolean Network Simulations and Use in Guard Cell CO2 Signaling

This study presents an open-source graphical interface for Boolean network simulations and applies it to an abscisic acid signaling network in guard cells, incorporating CO2 regulation.

Mammalian-unique eIF4E2 maintains GSK3β proline kinase activity to resist senescence against hypoxia

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

PacC-dependent adaptation and modulation of host cellular pH controls hemibiotrophic invasive growth and disease development by the rice blast fungus

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins

This study investigates the structural and functional role of a secondary iron-binding site in encapsulated ferritins using enzymatic assays, mass-spectrometry, and X-ray crystallography.

Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

The COMPASS-like complex modulates fungal development and pathogenesis by regulating H3K4me3-mediated targeted gene expression in Magnaporthe oryzae

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature

The paper replicates findings from two ASD mouse models and identifies informatics signatures showing activity levels distinguish them, with similar social behaviors when activity is controlled.

Conservation of the structural and functional architecture of encapsulated ferritins in bacteria and archaea

The paper structurally and functionally characterizes two EncFtn proteins from different species, showing conserved structure and catalytic activity despite diverse environments.

IFN-γ induces epithelial-to-mesenchymal transition of cancer cells via an unique microRNA processing

This study shows IFN-γ induces EMT in cancer cells by promoting IFIT5-mediated degradation of suppressive miRNAs, enhancing invasiveness and metastasis.