RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors
A. Khateb, A. Deshpande, Y. Feng, J. S. Lee, I. Lazar, B. Fabre, Y. Li, D. Finlay, Y. Fujita, T. Zhang, J. Yin, I. Pass, I. Livneh, C. Burian, J. R. Mason, , Z. A. Ronai
This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.
bioRxiv · Oct 25, 2020Cancer Biology