Evolutionary BiologybioRxivPreprint
Strong epistasis constrains the evolution of strict substrate specificity in apicomplexan lactate dehydrogenases
Jacob D. Wirth, Jeffrey I. Boucher, Changhan Xu…·Douglas L. Theobald
This study investigates the evolution of substrate specificity in apicomplexan lactate dehydrogenases, revealing strong epistasis that constrains evolutionary changes and limits reversion to ancestral phenotypes.