Author

Jacob D. Wirth

ORCID 0000-0002-6227-9321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Organism:rat· 1

Frequent Co-Authors

Changhan Xu· 1 shared Douglas L. TheobaldiD· 1 shared Jeffrey I. Boucher· 1 shared Scott ClasseniD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperEvolutionary Biology

Changhan Xu

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1 paper

Recent·Most cited

Evolutionary BiologybioRxivPreprintJun 21, 2023

Strong epistasis constrains the evolution of strict substrate specificity in apicomplexan lactate dehydrogenases

Jacob D. Wirth, Jeffrey I. Boucher, Changhan Xu…·Douglas L. Theobald

This study investigates the evolution of substrate specificity in apicomplexan lactate dehydrogenases, revealing strong epistasis that constrains evolutionary changes and limits reversion to ancestral phenotypes.

DOI 10.1101/2023.06.21.545977

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