HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway
R. Krause, COMMIT-KZN Team, J. Snyman, S.-H. Hwa, D. Muema, F. Karim, Y. Ganga, A. Ngoepe, Y. Zungu, I. Gazy, M. Bernstein, K. Khan, M. Mazibuko, N. Mthabela, D. Ramjit, , A. Leslie
This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.
bioRxiv · Jun 14, 2022Immunology