D. Ramjit

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts.

This study compares Mtb-specific IFN-γ and IgG responses in HIV-positive and HIV-negative individuals, finding higher IgG levels and lower QFT positivity in HIV-positive people with low CD4 counts.

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection

This study identifies distinct phenotypic, functional, and transcriptomic features of MR1-restricted MAIT cells in the human lung mucosa, showing their preservation in HIV infection.

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection.

This study compares HIV-induced gene expression in peripheral blood and bronchoalveolar cells, revealing distinct inflammatory signatures and compartment-specific effects.