Author

D. A. Pearce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. Fernando· 1 shared A. H. Sims· 1 shared A. Hill· 1 shared A. K. Turnbull· 1 shared A. Li· 1 shared A. N. Shajahan-Haq· 1 shared B. C. Gadomski· 1 shared C. Alt· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. Fernando

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

New, biomechanically sound tendon tissue after injection of uncultured, autologous, adipose derived regenerative cells in partial Achilles tendon defects in rabbits

C. Schmitz, C. Alt, T. Wuerfel, S. Milz, J. Dinzey, A. Hill, K. J. Sikes, L. Burton, J. Easley, H. L. Stewart, C. Puttlitz, B. C. Gadomski, K. Labus, D. A. Pearce, N. Maffulli, E. U. Alt

This study injects uncultured autologous adipose-derived regenerative cells into rabbit Achilles tendon defects and finds improved biomechanical properties compared to sham treatment.

bioRxiv · Feb 18, 2024 · PreprintBioengineering

Biogeographical patterns in soil bacterial communities across the Arctic region

L. A. Malard, M. Z. Anwar, C. S. A. Jacobsen, D. A. Pearce

This study examines Arctic soil bacterial communities, finding pH as the key environmental driver and identifying a core microbiome with high endemism potential.

bioRxiv · Aug 7, 2019Microbiology

SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)

C. M. Sevigny, S. Sengupta, Z. Luo, X. Liu, R. Hu, Z. Zhang, L. Jin, D. A. Pearce, D. Demas, A. N. Shajahan-Haq, R. Clarke

This study identifies SLC7A5 (LAT1) as a contributor to endocrine resistance in ER+ breast cancer by showing its role in metabolic reprogramming and growth suppression upon inhibition.

bioRxiv · Feb 21, 2019 · PreprintCancer Biology

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

C. Selli, A. K. Turnbull, D. A. Pearce, A. Li, A. Fernando, J. Wills, L. Renshaw, J. S. Thomas, J. M. Dixon, A. H. Sims

This study compares molecular changes in dormant and acquired resistant breast cancer tumors during extended letrozole treatment, finding distinct epigenetic alterations in resistant tumors.

bioRxiv · Sep 25, 2018Cancer Biology