A. Hill

Natural language processing charts transcriptome evolution to design combination cancer therapies

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.

New, biomechanically sound tendon tissue after injection of uncultured, autologous, adipose derived regenerative cells in partial Achilles tendon defects in rabbits

This study injects uncultured autologous adipose-derived regenerative cells into rabbit Achilles tendon defects and finds improved biomechanical properties compared to sham treatment.

Before and after delisting: population dynamics of North Atlantic humpback whales over two decades in the Gulf of Maine

The paper estimates population dynamics of North Atlantic humpback whales in the Gulf of Maine from 2000 to 2019, finding increased abundance but declining calf survival and sex ratio shifts.

STIL overexpression shortens lifespan and reduces tumor formation in mice

This study shows that STIL overexpression increases centrosome numbers, leading to aneuploidy and reduced tumor formation and lifespan in mice.

The evolutionary age-range size relationship is modulated by insularity and dispersal in plants and animals

The paper examines the relationship between evolutionary age and range size in species, finding that age correlates with larger ranges but this effect is modulated by insularity and dispersal ability.

Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization, and de novo cell types

This paper genetically engineers an endothelial niche in human kidney organoids to enhance vascularization, maturation, and the emergence of new cell types.

Development of a high-throughput barrier function assay using primary human gut organoids

The paper develops a high-throughput assay using primary human gut organoids to assess barrier function and response to TNF-α, showing dose-dependent rescue by antagonists.

Huntingtin Over-Expression Does Not Alter Overall Survival in Murine Cancer Models

This study tests if mutant huntingtin protects against cancer by over-expressing it in murine cancer models, finding no effect on survival.

Interlimb coordination in Parkinson's disease is minimally affected by a visuospatial dual task

This study examines how a visuospatial dual task affects interlimb coordination in Parkinson's disease patients during walking, finding minimal impact on coordination between limbs.

Effects of arm swing amplitude and lower limb asymmetry on motor variability patterns during treadmill gait

This study examines how arm swing amplitude and lower limb asymmetry affect motor variability during treadmill walking, finding specific impacts on joint angles and stability.

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

Tasmanian devil facial tumour-derived extracellular vesicles reveal mesenchymal transition markers and adhesion molecules related to metastasis.

This study analyzes extracellular vesicles from Tasmanian devil cancers to identify markers of metastasis and differential aggressiveness between two cancer types.

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination

This study shows that poor immunogenicity of EEF antigens does not prevent their susceptibility to CD8+ T cell killing, challenging the assumption that immunogenicity is a key criterion for vaccine development.

Freshwater sponge hosts and their green algae symbionts: a tractable model to understand intracellular symbiosis

This study examines the intracellular symbiosis between freshwater sponge Ephydatia muelleri and its green algal symbionts, identifying host responses and potential evolutionary pathways for stable mutualistic endosymbioses.

Arrhythmogenesis as the failure of repolarization

This paper proposes a new mechanism for arrhythmogenesis where cardiac cells failing to repolarize act as focal ectopic sources, leading to fibrillation, and shows that arrhythmia susceptibility is higher at tissue boundaries.

Integrating deep learning with microfluidics for biophysical classification of sickle red blood cells

This paper develops a deep learning workflow for automated classification of sickle red blood cells using microfluidic images, achieving accuracy comparable to human experts with significantly faster analysis.

PIP4Ks Suppress Insulin Signaling Through a Catalytic-Independent Mechanism

This study shows that PIP4Ks suppress insulin signaling through a non-catalytic mechanism by regulating PIP5K activity and PI(4,5)P2 levels.