Z. Luo

A spatially resolved multiomic single-cell atlas of soybean development

The paper constructs a spatially resolved multiomic single-cell atlas of soybean development, identifying cell types, chromatin regions, and gene regulatory networks involved in growth and nitrogen fixation.

pH-Sensitive Nanodroplets for Controlled Delivery of Berberine Chloride

This paper develops pH-sensitive nanodroplets for controlled berberine chloride delivery, showing high encapsulation efficiency and ultrasound-enhanced release.

Mating-compatibility genes employed as diagnostic markers to identify novel incursions of the myrtle rust pathogen Austropuccinia psidii

This study develops a diagnostic method using mating-type HD locus alleles to identify new incursions of the myrtle rust pathogen Austropuccinia psidii.

Evolution of plant cell-type-specific cis-regulatory elements

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

Dynamic evolution of the heterochromatin sensing histone demethylase IBM1

This study investigates the evolution of IBM1, an H3K9 demethylase, in flowering plants, showing its role in regulating gene body methylation and its dynamic evolution across species.

Simultaneous generation of osteoblasts and adipocytes by a bivalent differentiation medium from bone marrow stromal/stem cells (BMSCs)

This paper introduces a bivalent differentiation medium that enables BMSCs to simultaneously generate osteoblasts and adipocytes, with a method to assess lineage commitment using staining techniques.

Climate change decreases the likelihood of tropical forest community persistence with a strong mediation of plant-plant network structures

The paper assesses how climate change affects tropical forest community persistence by analyzing plant-plant interaction networks and structural stability over 25 years.

Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7

This study identifies Hmg20a and Nol9 as host factors restricting L. pneumophila replication by repressing Rab7, which is co-opted by the bacterium via SulF to facilitate phagosome biogenesis.

SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

SoyDNGP: A Web-Accessible Deep Learning Framework for Genomic Prediction in Soybean Breeding

SoyDNGP is a deep learning framework for genomic prediction in soybean breeding that outperforms existing methods in accuracy and efficiency, with a web interface for trait prediction and lookup.

A unique cell division protein critical for the assembly of the bacterial divisome

This study identifies Aeg1 as a new essential cell division protein in Acinetobacter baumannii that recruits FtsN to initiate cell division.

RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

Genome biology and evolution of mating type loci in four cereal rust fungi

This study analyzes mating type (MAT) loci in four cereal rust fungi, revealing allele status differences and recombination suppression patterns in their genomic regions.

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

OPUS-DSD: Deep Structural Disentanglement for cryo-EM Single Particle Analysis

OPUS-DSD improves cryo-EM reconstruction by resolving structural heterogeneity and enhancing homogeneity in datasets, outperforming existing methods on synthetic and real data.

Crystal structure of monkeypox H1 phosphatase, an Antiviral Drug Target

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

ICER controls HIV-1 infection and replication in elite controllers

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

A spatial and cellular distribution of neurotropic virus infection in the mouse brain revealed by fMOST and single cell RNA-seq

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

The paper determines the crystal structure of the Drosophila SARM1 ARM domain using MIRAS phasing, revealing insights into its regulation and activation mechanism.

Alisertib exerts KRAS allele specific anticancer effects in colorectal cancer

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

Three-dimensional Printing of Customized Bioresorbable Airway Stents

This paper develops bioresorbable airway stents using 3D printing and biomedical inks, showing biocompatibility and suitable degradation in rabbits.

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

Nfkbid is required for immunity and antibody responses to Toxoplasma gondii

This study identifies Nfkbid as essential for immunity and antibody responses to Toxoplasma gondii, showing its role in B cell activation, B-1 cell development, and vaccine efficacy.

Adipose tissue macrophages orchestrate β cell adaptation in obesity through secreting miRNA-containing extracellular vesicles

This study shows that adipose tissue macrophage-derived extracellular vesicles containing miRNA-155 regulate β cell function and proliferation in obesity.

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.