Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
K. R. Hixon, J. A. McKenzie, D. A. Sykes…·M. J. Silva
This study shows that ablating proliferating osteoblast lineage cells after fracture in mice leads to atrophic nonunion, providing a new model for studying this condition.
D. A. Sykes, M. Jimenez Roses, J. Reilly…·D. B. Veprintsev
This study investigates the kinetic selectivity of drugs targeting the β1-adrenoceptor, finding that hydrophobic interactions dominate ligand binding kinetics over combined polar and hydrophobic interactions.
B. L. Hoare, D. N. Tippett, A. Kaur…·D. B. Veprintsev
ThermoBRET quantifies GPCR thermostability using BRET without labelled ligands, revealing ligand effects on protein unfolding in non-purified samples.
C. R. Harwood, D. A. Sykes, B. Hoare…·D. B. Veprintsev
This paper demonstrates the functional solubilisation of the β2-adrenoceptor using DIBMA, showing improved thermal stability compared to detergent-based methods.