Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease
C. Young, M. Singh, K. J. Jackson, M. A. Field, T. J. Peters, S. Angioletti-Uberti, D. Frenkel, S. Ravishankar, M. Gupta, J. J. Wang, D. Agapiou, M. L. Faulks, G. Al-Eryani, F. Luciani, T. P. Gordon, , C. C. Goodnow
The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.
bioRxiv · Jan 7, 2024Immunology