Author

J. J. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

X. Zheng· 2 shared A. Carr· 1 shared A. D. Kelleher· 1 shared A. Riemenschneider· 1 shared B. Liang· 1 shared C. C. Goodnow· 1 shared C. Gibson· 1 shared C. Li· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

X. Zheng

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Author profile →

5 papers

Recent·Most cited

The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis

H. Sun, S. R. Long, M. Jiang, H. R. Zhang, J. J. Wang, Z. X. Liao, J. Cui, Z. Q. Wang

This study shows that Trichinella spiralis infection protects against colitis in mice by altering the gut microbiota, increasing SCFA-producing bacteria, and enhancing goblet cell differentiation and IL-10 levels.

bioRxiv · Apr 9, 2024 · PreprintMicrobiology

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

N. Zhang, J. Wu, F. Hossain, H. Peng, H. Li, C. Gibson, M. Chen, H. Zhang, S. Gao, X. Zheng, Y. Wang, J. Zhu, J. J. Wang, I. Maze, Q. Zheng

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

bioRxiv · Mar 20, 2024Biochemistry

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

C. Young, M. Singh, K. J. Jackson, M. A. Field, T. J. Peters, S. Angioletti-Uberti, D. Frenkel, S. Ravishankar, M. Gupta, J. J. Wang, D. Agapiou, M. L. Faulks, G. Al-Eryani, F. Luciani, T. P. Gordon, , C. C. Goodnow

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

bioRxiv · Jan 7, 2024Immunology

SIX4 Controls STING Expression Enhancing anti-PD-1 Efficacy

B. Liang, E. H. Zhang, Z. Ye, H. Storts, W. Jin, X. Zheng, O. Zaleski, X. Xing, J. J. Wang

This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.

bioRxiv · May 26, 2023 · PreprintCancer Biology

CASCADES, a novel SOX2 super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme

U. Shahzad, C. Li, M. Johnston, J. J. Wang, N. Sabha, F. S. Varn, A. Riemenschneider, S. Krumholtz, P. Meda, C. Smith, J. Karamchandani, J. K. Watts, R. G. W. Verhaak, M. Gallo, J. T. Rutka, S. Das

This study identifies CASCADES, a lncRNA that regulates stemness in glioblastoma cancer stem cells by epigenetically controlling SOX2 expression.

bioRxiv · Sep 5, 2020 · PreprintCancer Biology