A. Carr

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

Island biogeography theory and the gut: why taller people tend to harbor more diverse gut microbiomes.

The paper shows a positive association between human height and gut microbiome diversity, linking it to CDI risk and suggesting vegetable intake can mitigate this effect.

Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs

The paper identifies a PIP-box motif in Spd1 that competes with another PCNA binding site to regulate checkpoint activation in yeast.

Asymmetric cell division safeguards memory CD8 T cell development

This study shows that asymmetric cell division supports memory CD8 T cell development under strong TCR stimulation but not weak stimulation.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

Combined single cell proteomics and transcriptomics reveals discrete human tendon cells populations persist in vitro and on fibrous scaffolds

The paper identifies discrete human tendon cell populations using combined single cell proteomics and transcriptomics, showing some persist in vitro and on fibrous scaffolds, with pro-inflammatory clusters enriched on aligned fibres.

Synthetic lethality between TP53 and ENDOD1

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

Genome-wide analysis clarifies the population genetic structure of wild Gilthead Sea Bream (Sparus aurata)

This study uses SNP markers to analyze the genetic structure of wild Gilthead Sea Bream, identifying three genetic clusters and suggesting salinity differences drive differentiation.

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics

This study identifies eight distinct human tendon cell populations in healthy and diseased tissue using single-cell CITE-sequencing, revealing disease-specific changes in cell composition and marker expression.