A. Vidal

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity

This study shows that Cx43 enhances the effectiveness of BRAF/MEKi by reducing DNA repair, leading to increased DNA damage and cellular senescence, and proposes a novel therapeutic approach using sEVs.

Chromatin activity of IκBα mediates the exit from naïve pluripotency

This study shows that IκBα's chromatin activity, not its NF-κB signaling role, is critical for exiting naïve pluripotency in embryonic stem cells.

Genital microbiota in infertile couples

This study examines the genital microbiota of infertile couples to assess its association with fertility treatment outcomes.

Temporal dynamics of gut microbiomes in non-industrialized urban Amazonia

This study examines gut microbiome temporal dynamics in non-industrialized Amazonian populations, finding greater variability and frequent bacterial replacements compared to industrialized groups.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics

The paper investigates the immunogenicity of non-canonical HLA-I ligands from tumor cells and finds they are not recognized by autologous T-cells but can be targeted by donor T-cells, suggesting potential as immunotherapy targets.

Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021

The paper sequences and analyzes SARS-CoV-2 genomes from seven Latin American countries in 2021, identifying prevalent variants and genomic patterns.

Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

This study evaluates CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma, finding they reduce tumor growth and improve survival by inducing cell cycle arrest and senescence.

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

This study identifies KDM6A/UTX and KDM6B/JMJD3 as therapeutic targets in SMARCA4-deficient cancers, showing that their inhibition reduces tumor viability in mouse models.

Domestication of Campylobacter jejuni NCTC 11168

This study compares genetic and phenotypic variation in 23 isolates of the reference Campylobacter jejuni strain NCTC 11168, showing significant genomic and phenotypic differences despite being considered identical.

High prevalence and diversity of Extended-Spectrum β-Lactamase and emergence of Carbapenemase producing Enterobacteriaceae spp in wildlife in Catalonia

This study identifies a high prevalence and diversity of carbapenemase-producing Enterobacteriaceae in wildlife in Catalonia, highlighting the risk of environmental spread of antibiotic resistance genes.